| 12 matches found in 4 documents. Search time: 0.212 seconds. |
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Score: 9.00 |
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| Title: Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity .
| | Author: Tsai J Lee JT Wang W Zhang J Cho H Mamo S Bremer R Gillette S Kong J Haass NK Sproesser K Li L Smalley KS Fong D Zhu YL Marimuthu A Nguyen H Lam B Liu J Cheung I Rice J Suzuki Y Luu C Settachatgul C Shellooe R Cantwell J Kim SH Schlessinger J Zhang KY West BL Powell B Habets G Zhang C Ibrahim PN Hirth P Artis DR Herlyn M Bollag G | | Journal: Proc Natl Acad Sci U S A Citation: V : 105 P : 3041-6 Year: 2008 Type: MEDLINE | | Literature: oryza Field: abstract Doc ID: pub18287029 Accession (PMID): 18287029 | Matching Sentences:
[ Sen. 6, subscore: 2.00 ]: PLX4720 preferentially inhibits the active B-Raf ( V600E ) kinase compared with a broad spectrum of other kinases , and potent cytotoxic effects are also exclusive to cells bearing the V600E allele .
[ Sen. 1, subscore: 1.00 ]: BRAF ( V600E ) is the most frequent oncogenic protein kinase mutation known .
[ Sen. 3, subscore: 1.00 ]: Therefore , we pursued the development of specific kinase inhibitors targeting B-Raf , and the V600E allele in particular .
[ Sen. 5, subscore: 1.00 ]: PLX4720 , a 7-azaindole derivative that inhibits B-Raf ( V600E ) with an IC ( 50 ) of 13 nM , defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays .
[ Sen. 7, subscore: 1.00 ]: Consistent with the high degree of selectivity , ERK phosphorylation is potently inhibited by PLX4720 in B-Raf ( V600E ) -bearing tumor cell lines but not in cells lacking oncogenic B-Raf .
[ Sen. 8, subscore: 1.00 ]: In melanoma models , PLX4720 induces cell cycle arrest and apoptosis exclusively in B-Raf ( V600E ) -positive cells .
[ Sen. 9, subscore: 1.00 ]: In B-Raf ( V600E ) -dependent tumor xenograft models , orally dosed PLX4720 causes significant tumor growth delays , including tumor regressions , without evidence of toxicity .
[ Sen. 10, subscore: 1.00 ]: The work described here represents the entire discovery process , from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-Raf ( V600E ) -driven tumors .
| | Supplemental links/files: reference in endnote online text related articles pubmed citation | |
Score: 2.00 |
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| Title: An endornavirus from a hypovirulent strain of the violet root rot fungus , Helicobasidium mompa .
| | Author: Osaki H Nakamura H Sasaki A Matsumoto N Yoshida K | | Journal: Virus Res .
Citation: V : 118 ( 1-2 ) P : 143-9 Year: 2006 Type: ARTICLE | | Literature: oryza Field: abstract Doc ID: pub16417937 Accession (PMID): 16417937 | Matching Sentences:
[ Sen. 1, subscore: 1.00 ]: We determined the complete nucleotide ( nt ) sequence ( 16 , 614 nt ) of a large double-stranded ( ds ) RNA ( referred to as L1 dsRNA ) , previously identified as the hypovirulence factor from strain V670 of the violet root rot fungus , Helicobasidium mompa .
[ Sen. 8, subscore: 1.00 ]: L1 dsRNA of H mompa strain V670 was assigned to the genus Endornavirus , and here , we designate it as H mompa endornavirus 1-670 ( HmEV1-670 ) .
| | Supplemental links/files: reference in endnote online text related articles pubmed citation | |
Score: 1.00 |
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| Title: Design of sphingomonad-detecting probes for a DNA array , and its application to investigate the behavior , distribution , and source of Rhizospherous sphingomonas and other sphingomonads inhabiting an acid sulfate soil paddock in Kalimantan , Indonesia .
| | Author: Hashidoko Y Kitagawa E Iwahashi H Purnomo E Hasegawa T Tahara S | | Journal: Biosci . Biotechnol . Biochem . Citation: V : 71 ( 2 ) P : 343-51 Year: 2007 Type: ARTICLE | | Literature: oryza Field: abstract Doc ID: pub17284854 Accession (PMID): 17284854 | Matching Sentences:
[ Sen. 2, subscore: 1.00 ]: To investigate the behavior of sphingomonads inhabiting the rhizosphere of such acid-tolerant plants , we designed 13 different DNA array probes ( each of 72 mer ) specific to a group of sphingomonads , using a hypervariable V6 region of the 16S rRNA gene .
| | Supplemental links/files: reference in endnote online text related articles pubmed citation | |
Score: 1.00 |
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| Title: DGGE and 16S rDNA sequencing analysis of bacterial communities in colon content and feces of pigs fed whole crop rice .
| | Author: Wang HF Zhu WY Yao W Liu JX | | Journal: Anaerobe Citation: V : 13 P : 127-33 Year: 2007 Type: MEDLINE | | Literature: oryza Field: abstract Doc ID: pub17446093 Accession (PMID): 17446093 | Matching Sentences:
[ Sen. 2, subscore: 1.00 ]: Amplicons of the V6-V8 variable regions of bacterial 16S rDNA were analyzed by denaturing gradient gel electrophoresis ( DGGE ) , cloning and sequencing .
| | Supplemental links/files: reference in endnote online text related articles pubmed citation | |
