Score: 1.00 | Title: Worldwide esophageal cancer collaboration .
| Author: Rice TW Rusch VW Apperson-Hansen C Allen MS Chen LQ Hunter JG Kesler KA Law S Lerut TE Reed CE Salo JA Scott WJ Swisher SG Watson TJ Blackstone EH | Journal: Dis Esophagus Citation: V : 22 P : 1-8 Year: 2009 Type: In-Process | Literature: oryza Field: abstract Doc ID: pub19196264 Accession (PMID): 19196264 | Abstract: The aim of this study is to report assemblage of a large multi-institutional international database of esophageal cancer patients , patient and tumor characteristics , and survival of patients undergoing esophagectomy alone and its correlates .
Forty-eight institutions were approached and agreed to participate in a worldwide esophageal cancer collaboration ( WECC ) , and 13 ( Asia , 2 ; Europe , 2 ; North America , 9 ) submitted data as of July 1 , 2007 .
These were used to construct a de-identified database of 7884 esophageal cancer patients who underwent esophagectomy .
Four thousand six hundred and twenty-seven esophagectomy patients had no induction or adjuvant therapy .
Mean age was 62 +/- 11 years , 77% were men , and 33% were Asian .
Mean tumor length was 3 . 3 +/- 2 . 5 cm , and esophageal location was upper in 4 . 1% , middle in 27% , and lower in 69% .
Histopathologic cell type was adenocarcinoma in 60% and squamous cell in 40% .
Histologic grade was G1 in 32% , G2 in 33% , G3 in 35% , and G4 in 0 . 18% . pT classification was pTis in 7 . 3% , pT1 in 23% , pT2 in 16% , pT3 in 51% , and pT4 in 3 . 3% . pN classification was pN0 in 56% and pN1 in 44% .
The number of lymph nodes positive for cancer was 1 in 12% , 2 in 8% , 3 in 5% , and >3 in 18% .
Resection was R0 in 87% , R1 in 11% , and R2 in 3% .
Overall survival was 78 , 42 , and 31% at 1 , 5 , and 10 years , respectively .
Unlike single-institution studies , in this worldwide collaboration , survival progressively decreases and is distinctively stratified by all variables except region of the world .
A worldwide esophageal cancer database has been assembled that overcomes problems of rarity of this cancer .
It reveals that survival progressively ( monotonically ) decreased and was distinctively stratified by all variables except region of the world .
Thus , it forms the basis for data-driven esophageal cancer staging .
More centers are needed and encouraged to join WECC .
| Matching Sentences: [ Sen. 8, subscore: 1.00 ]: Histologic grade was G1 in 32% , G2 in 33% , G3 in 35% , and G4 in 0 . 18% . pT classification was pTis in 7 . 3% , pT1 in 23% , pT2 in 16% , pT3 in 51% , and pT4 in 3 . 3% . pN classification was pN0 in 56% and pN1 in 44% .
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