Abstract: Cdc2 proteins are well characterized as protein kinases and are functionally involved in the control of the G2 to M transition during cell division . cdc2 proteins ( cdc2Sp , CDC28 and CDC2Gg ) and proteins sharing a high degree of similarity with cdc2 proteins ( EG1 and DM2C ) , and therefore belonging to the same structural family , were analyzed using Fourier transform of the coded sequences .
Characteristic code/frequency pairs ( 0 . 140 , 0 . 148 and 0 . 238 ) distinguish the cdc2 proteins from the related proteins .
The frequencies 0 . 140 , 0 . 148 and 0 . 238 ( and the associated codes ) allow discrimination between all cdc2 proteins ( cdc2Sp , CDC28 , CDC2Gg , CDC2Hs , CDC2Mm , CDC2Dm , CDC2Ms ) and related proteins ( EG1 , DM2C , MO15 , GTA , PHO85 , KSS1 , PSKJ3 , FUS3 , KIN28 ) , thus providing the first evidence for predicting cdc2 function from a sequence .
A rice cdc2 homolog ( R2 ) did not match the cdc2 proteins and is , therefore , unlikely to be a cdc2 protein .
Pertinent patterns in the cdc2 proteins were searched , and mapped to the 90-210 region ( numbering from cdc2 of S pombe ) which correlates well with the putative cyclin binding domain of the cdc2 proteins .
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