Score: 4.00 | Title: Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease .
| Author: Martinez CH Chen YH Westgate PM Liu LX Murray S Curtis JL Make BJ Kazerooni EA Lynch DA Marchetti N Washko GR Martinez FJ Han MK | Journal: Thorax Citation: V : 67 P : 399-406 Year: 2012 Type: In-Process | Literature: oryza Field: abstract Doc ID: pub22514236 Accession (PMID): 22514236 | Abstract: BACKGROUND : The value of quantitative CT ( QCT ) to identify chronic obstructive pulmonary disease ( COPD ) phenotypes is increasingly appreciated .
The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St Georges Respiratory Questionnaire ( SGRQ ) and Body-Mass Index , Airflow Obstruction , Dyspnea and Exercise Capacity Index ( BODE ) .
METHODS : 1200 COPDGene subjects meeting Global Initiative for Chronic Obstructive Lung Disease ( GOLD ) criteria for COPD with QCT analysis were included .
Total lung emphysema was measured using the density mask technique with a -950 Hounsfield unit threshold .
An automated programme measured mean wall thickness ( WT ) , wall area percentage ( WA% ) and 10 mm lumenal perimeter ( pi10 ) in six segmental bronchi .
Separate multivariate analyses examined the relative influence of airway measures and emphysema on SGRQ and BODE .
RESULTS : In separate models predicting SGRQ score , a 1 unit SD increase in each airway measure predicted higher SGRQ scores ( for WT , 1 . 90 points higher , p=0 . 002 ; for WA% , 1 . 52 points higher , p=0 . 02 ; for pi10 , 2 . 83 points higher p<0 . 001 ) .
The comparable increase in SGRQ for a 1 unit SD increase in emphysema percentage in these models was relatively weaker , significant only in the pi10 model ( for emphysema percentage , 1 . 45 points higher , p=0 . 01 ) .
In separate models predicting BODE , a 1 unit SD increase in each airway measure predicted higher BODE scores ( for WT , 1 . 07-fold increase , p<0 . 001 ; for WA% , 1 . 20-fold increase , p<0 . 001 ; for pi10 , 1 . 16-fold increase , p<0 . 001 ) .
In these models , emphysema more strongly influenced BODE ( range 1 . 24-1 . 26-fold increase , p<0 . 001 ) .
CONCLUSION : Emphysema and airway disease both relate to clinically important parameters .
The relative influence of airway disease is greater for SGRQ ; the relative influence of emphysema is greater for BODE .
| Matching Sentences: [ Sen. 5, subscore: 1.00 ]: An automated programme measured mean wall thickness ( WT ) , wall area percentage ( WA% ) and 10 mm lumenal perimeter ( pi10 ) in six segmental bronchi . [ Sen. 7, subscore: 1.00 ]: RESULTS : In separate models predicting SGRQ score , a 1 unit SD increase in each airway measure predicted higher SGRQ scores ( for WT , 1 . 90 points higher , p=0 . 002 ; for WA% , 1 . 52 points higher , p=0 . 02 ; for pi10 , 2 . 83 points higher p<0 . 001 ) . [ Sen. 8, subscore: 1.00 ]: The comparable increase in SGRQ for a 1 unit SD increase in emphysema percentage in these models was relatively weaker , significant only in the pi10 model ( for emphysema percentage , 1 . 45 points higher , p=0 . 01 ) . [ Sen. 9, subscore: 1.00 ]: In separate models predicting BODE , a 1 unit SD increase in each airway measure predicted higher BODE scores ( for WT , 1 . 07-fold increase , p<0 . 001 ; for WA% , 1 . 20-fold increase , p<0 . 001 ; for pi10 , 1 . 16-fold increase , p<0 . 001 ) .
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