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Under Development: Last updated 02-01-2003 by eek. |
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| Action | Allele | Biological Process | Cell and Cell Group | Cellular Component | Characterization | Clone | Comparison | Consort | Descriptor | Drugs and Small Molecules | Effect | Entity Feature | Gene | Involvement | Life Stage | Localization in Time or Space | Pathway | Phenotype | Purpose | Method | Molecular Function | Mutant | Nucleic Acid | Organism | (Physical) Association | Regulation | Sex | Spatial Relation | Strain | Time Relation | Transgene |
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Definition: A group of physical features on a chromosome that act together in such a way to eventually (via transcription and perhaps translation) result in a gene product.
Example: let-60
Definition: An artificially constructed gene (or genes) that is inserted into the germline in a manner that ensures its function, replication and tranmission as a normal gene. top
Example: syIs9
Definition: One of a number of different forms of a gene that occur at the same locus but differ in base sequence.
Example: ad606
D) Cell and Cell Group (Attribute Type: (Name, Lineage, Group)) top
Definition: The basic subunit of any living thing, typically containing genetic material, an energy-producing system, and other components, all surrounded by a wall and/or membrane. A cell group is a collection of cells that show very similar, if not identical phenotypic characteristics.
Example: sensory neuron, muscle, AB.p
E) Cellular component (Attribute Source: (Go, Textpresso)) top
Definition: Subcellular structures, locations, and macromolecular complexes.
Examples: SnoRNA, mitochondrion, nucleus, telomere, and origin recognition complex.
Definition: Nucleotides that are the subunits of DNA and RNA..
Example: Cytosine, Uracil
Definition: A virus or a unicellular or multicellular prokaryote or eukaryote.
Example: C. elegans, Homo sapiens, S. pombe
H) Entity Feature (Attribute Type: (Protein, DNA, RNA, other)) top
Definition: A feature or component of a biological entity.
Example: Transposon, Codon, Valine
Definition: The functional, morphological or time stages through which an organism passes.
Example: Embryo
Definition: A set of observable physical characteristics of an individual organism.
Example: Fog, Dumpy, Phenotype, Wildtype
Definition: An intraspecific group of organisms that possess only one or a few distinctive traits and are maintained as an artificial breeding group.
Example: N2
Definition: The state of condition of an organism which comes to expression in the production of germ cells.
Example: male
M) Drugs and Small Molecules (Attribute Type: (antibiotic, unknown)) top
Definition: Any chemical substance that affects the functioning of living things directly or indirectly.
Example: Ampicillin
O) Molecular Function (Attribute Source: (Go, Textpresso); Attribute Protein: (yes, no)) top
Definition: The tasks performed by individual gene products.
1st example: Transcription factor
2nd example: DNA helicase
Definition: Indicates that something is produced by or follows a mutation; also a mutant gene.
1st example: ced-1 mutant background.
2nd example: Deformed tail region.
Definition: A vector used for cloning DNA.
Examples: Cosmid, cDNA, YAC, yk1215d07
A) (Physical) Association (Attribute Type: (positive, negative, unknown))
Definition: A spatial connectivity supported by noncovalent bonds.
Example: The PHA-4 protein binds to a regulatory region of the pharynx myosin-encoding myo-2 gene.
B) Consort (abstract association) (Attribute Type: (positive, negative, unknown)) top
Definition: An abstract connectivity established by an abstract concept or unspecified process or function.
1st example: Another partner for sdc-2 is sdc-3.
2nd example: Dpy genes and sdc genes work together in all aspects of dosage compensation.
C) Effect (Attribute Type: (positive, negative, unknown)) top
Definition: The power to bring about a result upon an entity.
1st example: We examined tkr-1 and tkr-2 transgenics for effects on stress resistance and longevity.
2nd example: Therefore , the possibility existed that RNAi of pdk-1 actually abolishes pdk-1 gene activity.
Definition: Indication that a thing or part is specially fitted or used as or for which a thing exists.
Example: UNC-45 is a component of thick filaments and functions as a stabilizer for MHC B.
E) Pathway (Attribute Type: (downstream, upstream, parallel, bypass, redundant, unknown)) top
Definition: A (hierarchical) sequence, network, or part of it, of reactions or processes that involve biological entities.
Example: Therefore, the genes acting downstream of gsk-3 in the Wnt pathway are not required for proper EMS spindle orientation.
F) Regulation (Attribute Type: (positive, negative, unknown)) top
Definition: The act of fixing or adjusting a quality (time, amount, degree, or rate) of an entity upon itself (autoregulation) or on another entity or entities (A regulates B).
1st example: Third , son-1 ( sy549 ) enhances the phenotypes of a weak allele of lin-17 to null-like phenotypes.
2nd example: Interestingly, pie-1 mutants inappropriately derepress the transcription of several genes in germline blastomeres.
G) Comparison (Attribute Type: (similar, identical, different)) top
Definition: An examination of two or more items to establish similarities and dissimilarities.
1st example: Unc-129 mutants on their own exhibit defects in dorsalward axonal projection that resemble those caused by unc-6 or unc-5 mutations.
2nd example: The general gene organization is similar to that of Drosophila and vertebrates but the gene expression mechanism was somewhat different.
H) Spatial Relation (Attribute Type: (close, distant, unknown)) top
Definition: An aspect or quality (as resemblance) that connects two or more things or parts in space.
1st example: However, unc-25 and unc-47 are 0.15 map units apart .
2nd example: Reporter gene transformation studies demonstrated that regulation of this gene is mediated by a compact region close to the transcription start site.
I) Time Relation (Attribute Type: earlier, later, simultaneously) top
Definition: An aspect or quality (as resemblance) that connects two or more things or parts in time.
Example: The factors that regulate these genes will be expressed in the same cell lineage but earlier than the expression of target genes.
Definition: To be present in an event or process as an active element or member.
1st example: mec-7 is a b-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans.
2nd example: Two predicted transcription factors, skn-1 and pop-1, are necessary for the MS developmental program, including the production of pharyngeal cells.
3rd example: This mutual exclusivity of cell fates presumably involves a network of gene activity that not only activates genes appropriate to that cell type but represses all others, thereby ensuring an either-or decision.
4th example: Pop-1 is involved in Wnt-dependent asymmetric cell division of the EMS blastomere.
Definition: The description of the character or quality of something.
1st example: Similarly, the ges-1 gene promoter contains a pair of GATA motifs that are required for proper intestine-specific expression.
2nd example: The gene has nine small introns typical of C elegans.
L) Localization in Time or Space (Attribute Type: (spatial, temporal, general, unknown)) top
Definition: A position or site occupied or available for occupancy or marked by some distinguishing feature in time or space.
1st example: We ablated all cells in the gonad primordium of let-23 ( sa62 ) unc-4 ( e120 ) mnC1 or let-23 ( sa62 ) unc-4 ( e120 ) let-23 ( sa62 ) unc-4 ( e120 ) larvae before the first division of the somatic gonad precursors Z1 and Z4.
2nd example: We picked let-23 ( sa62 ) unc-4 ( e120 ) animals or unc-4 control animals at the L4 stage .
3rd example: The ced-4 ( n1162 ) allele contains an ochre stop mutation at codon 79 and is probably a molecular and genetic null allele.
Definition: A way, technique, or process for doing something.
Example: Cell ablation, Immunoprecipitation
N) Biological Process (Attribute Source: (Go, Textpresso); Attribute Type: (molecular, cellular, organismal, general); Attribute Biosynthesis: (transcription, translation, expression, replication, other, no)) top
Definition: Broad biological goals, such as mitosis or purine metabolism, that are accomplished by ordered assemblies of molecular functions.
1st example: The expression of syn-4 in the seam cells of L1 larvae might indicate that syn-4 plays a role in secretion of the worm cuticle.
2nd example: All four fly msl genes are transcribed in both sexes.
Definition: The exertion of energy or influence on any entity.
1st example: sel-12 activity facilitates the activity of LIN-12 and GLP-1 , two receptors of the LIN-12yNotch family.
2nd example: This data supports the idea that gld-2(lf):: gld-1(lf) double mutants never enter meiosis.
3rd example: Neither the sma6(e1482) nor the sma-4(e805) alleles elicit tail defects.
Definition: A word or phrase that has the function of describing the state or condition of an entity.
1st example: Sterility is caused by necrotic death of germ cells during larval development.
2nd example: Thus, fertile mes-1 adults arise from embryos that undergo an apparently normal lineage.
Auxiliary (forms of the verbs 'be' and 'have'), Bracket, Determiner, Conjunction (and, or, because, since, although,...), Conjecture (could, might, should, suggests... to indicate the certainty of a statement), Negation, Pronoun, Preposition, Punctuation.
28/05/02 hmm and ek